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金 洪

发布时间 :2016年06月13日 浏览量 :2381

金洪,博士,助理研究员

办公室电话:028-85415611

邮箱: [email protected]

学习和工作经历:

1995 - 1999,四川师范大学,化学教育,学士

2003 - 2006,网赌正规网站排名,有机化学,硕士

2006 - 2009,网赌正规网站排名,化学生物学,博士

2009 - 2012,中国石油西南油气田分公司和网赌正规网站排名,化学工程与技术,博士后

2012 - 2013,中国石油西南油气田分公司天然气研究院,工程师

2013 - 至今,十大老品牌网赌,助理研究员

研究方向及研究内容:

1、绿色农药的化学与生物学研究

针对我国农业病虫害发生危害的特点,以植物源农药活性成分或现有化学农药为基础,创制对环境友好的、具有自主知识产权的绿色农药新品种;结合生物活性综合评价和作用机制研究,发现新型先导化合物;利用计算机辅助农药分子设计,通过构效关系分析,设计合成并筛选出具有农药生物活性的新化合物;绿色化学农药的合成方法研究。

2、退化草地的生物防治综合配套技术研究

针对草地退化严重、草畜失衡、生产力低效问题,以现有退化草地的生物防治技术为基础,定期监测示范区鼠虫害发生发展动态,并结合该领域生物灾害发生规律,分析评估生物灾害发生风险,开展预测预报技术研究;同时针对不同退化程度草地,开展以生态防治为重点的鼠虫害综合防治技术的研究和示范,制定防控技术规范。

主持和参与项目:

1“十三五”国家重点研发计划项目子课题,2016YFC0502004-02,退化草地生物综合防治技术和示范,2016-2020,主持。

2、“十三五”国家重点研发计划项目子课题,2017YFD0200503-4,青藏高原极端微生物菌株的筛选、鉴定及农用代谢产物研究,2017-2020,主持。

3. 第二次青藏高原综合科学考察研究子专题,2019QZKK040404,生态工程技术评估与绩效管理,2019.11-2024.10,参与。

4. 国家自然科学基金,31272068,几类含呋喃环仿生农药分子结构改造及作用机理研究,2013-2016,参与。

部分代表性论文:

1. Yongtian Zhao, Na Yang, Yiming Deng, Ke Tao, Hong Jin*, Taiping Hou, Mechanism of action of novel pyrazole carboxamide containing a diarylamine scaffold against Rhizoctonia solani, Journal of Agricultural and Food Chemistry, 2020, 68, (40), 11068-11076.

2. Jian Yang, Yongtian Zhao, Jun Wan, Mingfang Jiang, Hong Jin*, Ke Tao, Taiping Hou, Synthesis and biological evaluation of novel benodanil-heterocyclic carboxamide hybrids as a potential succinate dehydrogenase inhibitors, Molecules, 2020, 25, 4291.

3. Aigui Zhang, Ying Yue, Jian Yang, Jiaxing Shi, Ke Tao, Hong Jin*, Taiping Hou, Design, synthesis, and antifungal activities of novel aromatic carboxamides containing a diphenylamine scaffold, Journal of Agricultural and Food Chemistry, 2019, 67, (17), 5008-5016.

4. Yuanhang Ren, Jiaxing Shi, Yangping Mu, Ke Tao, Hong Jin*, Taiping Hou, AW1 neuronal cell cytotoxicity: The mode of action of insecticidal fatty acidsJournal of Agricultural and Food Chemistry, 2019, 67, 43, 12129-12136.

5. Aigui Zhang, Ying Yue, Yihua Yang, Jian Yang, Ke Tao, Hong Jin*, Taiping Hou*, Discovery of N-(4-fluoro-2-(phenylamino)phenyl)-pyrazole-4-carboxamide as potential succinate dehydrogenase inhibitors, Pesticide Biochemistry and Physiology, 2019, 158, 175-184.

6. Yi Wang, Xiaochuan Chen, Hong Jin*, Yuanhua Wang*, Mild and practical dirhodium(II)/NHPImediated allylic and benzylic oxidations with ambient air as the oxidant, Chemistry-A European Journal, 2019, 25, 14273-14277.

7. Aigui Zhang, Yihua Yang, Ying Yue, Ke Tao, Taiping Hou*, Hong Jin*, N-[2-[(3-Chlorophenyl)amino]-phenyl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide: Synthesis, crystal structure, molecular docking and biological activities, Chemistry & Biodiversity, 2019, 16, e1900118.

8. Yuanhang Ren, Liqin He, Hong Jin*, Ke Tao*, Taiping Hou, Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2, Food and Agricultural Immunology, 2018, 29, 964-975.

9. Aigui Zhang, Jingya Zhou, Ke Tao, Taiping Hou, Hong Jin*, Design, synthesis and antifungal evaluation of novel pyrazole carboxamides with diarylamines scaffold as potent succinate dehydrogenase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2018, 28, 3042-3045.

10. Xiao-Xiao Zhang, Hong Jin*, Yuan-Jie Deng, Xu-Heng Gao, Yong Li, Yong-Tian Zhao, Ke Tao, Tai-Ping Hou*, Synthesis and biological evaluation of novel pyrazole carboxamide with diarylamine-modified scaffold as potent antifungal agents, Chinese Chemical Letters, 2017, 28, 1731-1736.

11. Hongyu Wang, Xuheng Gao, Xiaoxiao Zhang, Hong Jin*, Ke Tao, Taiping Hou* Design, synthesis and antifungal activity of novel fenfuram-diarylamine hybridsBioorganic & Medicinal Chemistry Letters, 2017, 27(1), 90-93.

12. Hong Jin*, Jingya Zhou, Tao Pu, Aigui Zhang, Xuheng Gao, Ke Tao, Taiping Hou, Synthesis of novel fenfuram-diarylether hybrids as potent succinate dehydrogenase inhibitors, Bioorganic Chemistry, 2017, 73, 76-82.

13. Fang Wen, Hong Jin*, Ke Tao*, Taiping Hou, Design, synthesis and antifungal activity of novel furancarboxamide derivatives, European Journal of Medicinal Chemistry, 2016, 120(2), 244-251.

14. Mingjing Chen, Hong Jin*, Ke Tao, Taiping Hou, Synthesis and bioactivity evaluation of novel benzamide derivatives containing a diphenyl ether moiety, , 2014, 39(4): 187-192.

15. Hong Jin, Liyu Xiang, Fang Wen, Ke Tao, Qian Liu, Taiping Hou*, Improved synthesis of chalconoid-like compounds under ultrasound irradiation, Ultrasonics Sonochemistry, 2008, 15(5): 681-683.

16. Hong Jin, Haoyu Zhao, Feihu Zhao, Shihong Li, Wei Liu, Guoping Zhou, Ke Tao, Taiping Hou*, Efficient epoxidation of chalcones with urea-hydrogen peroxide under ultrasound irradiation, Ultrasonics Sonochemistry, 2009, 16(3), 304-307.

17. Hong Jin, Yucong Geng, Zhiyi Yu, Ke Tao, Taiping Hou*, Lead optimization and anti-plant pathogenic fungi activities of daphneolone analogues from Stellera chamaejasme L., Pesticide Biochemistry and Physiology, 2009, 93(3), 133-137.

部分授权专利:

1. 侯太平,高续恒,金洪,郭聪. 一种草原害鼠的持续性控制方法. 中国发明专利:ZL 201810134602.4.

2. 侯太平,查艳梅,陶科,金洪,岳莹,刘英. 泡盛曲霉菌株及其在农业害虫防治领域的用途. 中国发明专利:ZL 201710204653.5.

3. 侯太平,张肖肖,金洪,陶科. 含二芳胺基的吡唑甲酰胺类化合物及其在农药中的应用. 中国发明专利:ZL 201610019343.1.

 

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